Here is the raw list of the 46 CPython issues I opended between 2016-04-21 and 2017-02-10 to implement my FASTCALL optimization. Most issues created in 2016 are already part of Python 3.6.0, some are already merged into the future Python 3.7, the few remaining issues are still open.

27 FASTCALL issues

3 issues converting functions to FASTCALL